The latest advances in genome sequencing indicate proteases occur naturally in all organisms and account for about 2% of the human genome and 1–5% of genomes of infectious organisms. The human genome ...
Biochemical assays are a common approach used to identify inhibitors of epigenetic-modifying enzymes. Challenges that arise when designing these assays are centered on choosing histone substrates that ...
In the ClpXP compartmental protease, ring hexamers of the AAA + ClpX ATPase bind, denature and then translocate protein substrates into the degradation chamber of the double-ring ClpP 14 peptidase. A ...
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