New standards may help push more drugmakers to use a synthetic product for critical drug safety testing, instead of one made from horseshoe crab blood that has long drawn criticism. The U.S.

Limulus polyphemus - the Atlantic horseshoe crab, found along the Atlantic coast of the United States and the Southeast Gulf of Mexico. By Breese Greg, U.S. Fish and Wildlife Service, CC 3.0. Limulus ...

In this episode of C&EN Uncovered, host Craig Bettenhausen speaks with C&EN assistant editor Laurel Oldach about the use of horseshoe crab blood in pharmaceutical endotoxin testing, the challenges of ...

As thoroughly covered in your recent article (C&EN, Oct. 28, 2024, page 26), the issue of replacing the traditional natural product test for endotoxin, limulus amoebocyte lysate (LAL), with a ...

Each May, hundreds of thousands of horseshoe crabs climb onto beaches along the eastern coast of the United States. An invertebrate’s “Love Island,” males compete to procreate with the largest females ...

Novel Approach to Achieving Consistent Results with the Limulus Amebocyte Lysate Test The standard tool for screening endotoxins—highly toxic, heat-stable lipopolysaccharides that constitute the outer ...

WILMINGTON, Del.— A coalition of pharmaceutical companies and conservation groups launched the Sustainability Scorecard for Endotoxin Testing to accelerate the adoption of synthetic alternatives to ...

Charles River International Laboratories, Inc. CRL recently launched Endosafe Trillium rCR cartridges, which combine its hallmark Endosafe cartridge technology with recombinant cascade reagent (rCR).

With copper-blue blood prized by modern medicine and a body plan older than dinosaurs, the horseshoe crab reveals how ancient ...