Harvard Medical School researchers have uncovered crucial insights into how an emerging class of antiviral drugs works.

Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, No. 52 (December 26, 2019), pp. 26941-26950 (10 pages) Autophagy is a powerful host defense that restricts ...

A common hallmark of viral genome replication is a high mutation rate, which can aid in their ability to evade new treatments and acquire resistance to once-effective antiviral medications. Now, a new ...

All organisms — from fungi to mammals — have the capacity to evolve and adapt to their environments. But viruses are master shapeshifters with an ability to mutate greater than any other organism. As ...

Researchers have resolved the first high-resolution structures of the herpes simplex virus origin-binding protein (OBP), revealing unexpected mechanisms of viral DNA replication and uncovering ...

In a recent study published in Communications Biology, researchers evaluated the therapeutic efficacy of Navoximod, combined with herpes simplex 1 (HSV-1) virotherapy, against hepatocellular carcinoma ...