Dual gene deletion reveals potential biomarkers for predicting immunotherapy success

The deletion of two cancer genes, CHD1 and MAP3K7, improves how well tumors respond to cancer immunotherapy and could be used ...
EurekAlert!

Centromere protein I, a cell cycle checkpoint gene, accelerates tumor progression via the hippo pathway and mediates immune escape in hepatocellular carcinoma

Cell cycle checkpoint-related genes (CCCRGs) are implicated in the development and progression of hepatocellular carcinoma ...
EurekAlert!

Immunotherapy success could be predicted with new biomarkers

Scientists pinpoint two cancer genes that when deleted, improve the vulnerability of tumour cells to immunotherapy.
ascopubs.org

The predictive role of TRAIL gene expression in immune checkpoint inhibitor (ICI)-treated patients (pts).

Biological determinants of immune exclusion in non-small cell lung cancer: An analysis of the precision medicine BIP study. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This ...
The Scientist

Releasing the Brakes: The Role of Immune Checkpoint Inhibitors in Cancer Therapy

Humans have been attempting to combat cancer since the time of the Ancient Egyptians, and recent decades have seen remarkable progress. However, tumor cells have developed sophisticated ways to evade ...
Frontiers

Immune-Checkpoint Inhibitors and Immunometabolic Reprogramming in Cancer Immunotherapy

Cancer represents a key challenge in medical science, manifesting as a disease where the immune system fails to recognize and eliminate tumor cells. The phenomenon of immune evasion by cancer cells ...