Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many ...

The SWI/SNF Ig-Fold for Transcription Factor Interactions or 'SWIFT' domain on mSWI/SNF chromatin remodeling complexes engage ...

The FIPO23 trial: First-in-human phase I/II study of XON7 in advanced solids tumors. ATHENA: A phase 1/2 study of AZD5851, a chimeric antigen receptor (CAR) T-cell therapy directed against GPC3 in ...

Scientists discovered how macrophages, which act as the immune system's first line of defense, tailor their specific responses to various intruders through the independent and cooperative functions of ...

The SWI/SNF protein complex was already known to carry out such changes, but it was unclear whether each of the three variants did so in a unique way or led to distinct macrophage behavior. To learn ...

Salk scientists determine how three variants of a protein complex coordinate pathogen-specific immune responses in mice; findings may lead to new therapeutics for inflammation LA JOLLA (June 5, ...