Exploring Small Molecules Targeting Protein–Protein Interactions …
In this Special Issue, we witness a confluence of cutting-edge research and insightful review articles, providing a inclusive overview of the current state of small-molecule PPI modulators.
New insights into protein–protein interaction modulators in drug ...
Dec 6, 2024 · Additionally, the key challenges in small molecule PPI modulation are highlighted along with tactics to harness protein dynamics while achieving optimal selectivity and efficacy in inhibition.
Recent advances and future trends for protein–small molecule ...
Aug 1, 2025 · In this review, we discuss and present the various methods and applications that have recently been used for predicting protein–small molecule interactions using PLMs. We begin with an …
A multimodal Transformer Network for protein-small molecule
May 20, 2024 · Understanding how proteins interact with small molecules, such as drugs, is critical to advancing medical, biological, and biotechnological research. Our work introduces ProSmith, a …
Detecting Protein–Small Molecule Interactions Using Limited …
May 29, 2020 · One method to study protein–small molecule interactions in a complex sample is limited proteolysis–mass spectrometry (LiP-MS). In this approach, a small molecule is added to a complex …
Protein-Small Molecule Biomolecular Interactions - a Retrospective ...
Jun 20, 2024 · Surface Plasmon Resonance (SPR) is an invaluable technique that generates information- rich data for a variety of biomolecular interactions. Researchers utilize SPR to …
Detection of small molecule compounds bound to proteins
Jun 1, 2024 · Therefore, probing the interaction, affinity size, and binding mode of small molecule compounds with target proteins is an important means and way to reveal the mechanism of drug action.
Protein-Small Molecule Interactions in Native Mass Spectrometry
Apr 27, 2022 · In this review, we describe potential and proven applications of native MS in the study of interactions between small, drug-like molecules and proteins, including large multiprotein complexes …
Targeting Protein-Protein Interactions by Small Molecules
This book covers the state-of-the-art strategies developed for protein-protein interaction (PPI) inhibitors, and highlights the success stories in new drug discovery and development. It demonstrates the …
Exploring Small Molecules Targeting Protein–Protein Interactions …
Nov 22, 2023 · Specific focus on small molecules as modulators of PPIs will make new inroads in drug development, offering unprecedented opportunities to reshape the pharmacological landscape. PPIs …